Pentose metabolic process

Across TCGA patient cohorts, RNA activity of the Pentose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR65, IGHV1-18, and FMNL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pentose metabolic process activity versus GPR65 in COAD (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GPR65 →	-0.532	-0.139	.002	<.001	3	5
CCRCC	IGHV1-18 →	-1.338	-0.135	.001	.001	3	5
CCRCC	FMNL1 →	-0.471	-0.158	.002	.003	3	5
UCEC	THEMIS2 →	-0.697	-0.072	.003	.007	3	4
UCEC	CXCL13 →	-1.371	-0.076	<.001	.001	3	4
UCEC	ZNF80 →	-0.238	-0.070	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019321 vs GPR65 — COAD

Explore this scatter interactively →