Pentose metabolic process

Across TCGA cell cohorts, RNA activity of the Pentose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSL1, DCAF10, and SYNGAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MSL1 grouped by Pentose metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MSL1 →	+0.783	+1.160	.003	.001	3	4
URINARY_TRACT	DCAF10 →	+0.498	+1.405	.004	.008	3	4
UPPER_AERODIGESTIVE_TRACT	SYNGAP1 →	+1.150	+1.417	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	GTF2I →	+1.157	+1.434	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ADNP →	+0.852	+1.110	.002	.009	3	3
UPPER_AERODIGESTIVE_TRACT	NFAT5 →	+1.473	+1.596	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MSL1 by Pentose metabolic process activity — LUNG_SCLC

Explore this box plot interactively →