Pentose metabolic process

Across TCGA cell cohorts, RNA activity of the Pentose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IER3, G6PD, and KCNMB4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pentose metabolic process activity versus IER3 in BLOOD_Lymphoma (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IER3 →	-2.380	-0.266	.001	.001	3	5
LARGE_INTESTINE	G6PD →	+1.690	+0.291	.002	<.001	3	5
BLOOD_Lymphoma	KCNMB4 →	+2.040	+0.258	<.001	.001	3	4
LARGE_INTESTINE	DCXR →	+0.747	+0.259	.004	.003	3	4
KIDNEY	PPP1R3G →	-1.091	-0.268	.006	.003	3	4
LUNG_SCLC	BCL10 →	-0.750	-0.182	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019321 vs IER3 — BLOOD_Lymphoma

Explore this scatter interactively →