Hexose catabolic process

Across TCGA patient cohorts, RNA activity of the Hexose catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MNDA_S227, C2CD2L_S468, and CLASP2_S459, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hexose catabolic process activity versus MNDA_S227 in COAD (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MNDA_S227 →	+1.750	+0.042	<.001	.002	3	4
LUAD	C2CD2L_S468 →	+0.456	+0.024	<.001	.003	3	4
LUAD	CLASP2_S459 →	-0.224	-0.020	.004	.006	3	4
LUAD	DSG2 →	+0.393	+0.031	.004	.001	3	4
GBM	GTPBP1 →	-0.230	-0.029	<.001	<.001	3	4
LUAD	HECA →	-0.119	-0.019	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019320 vs MNDA_S227 — COAD

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