Hexose catabolic process

Across TCGA patient cohorts, RNA activity of the Hexose catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HILPDA, KLF10, and TRBV5-5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hexose catabolic process activity versus HILPDA in CCRCC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HILPDA →	+0.967	+0.116	.001	.003	3	4
PDAC	KLF10 →	+0.353	+0.223	.004	<.001	3	4
PDAC	TRBV5-5 →	-0.766	-0.164	<.001	.002	3	4
CCRCC	ZP3P1 →	+0.235	+0.128	.004	.003	3	4
CCRCC	SNW1 →	+0.297	+0.116	<.001	.004	3	4
CCRCC	STRN3 →	+0.262	+0.104	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019320 vs HILPDA — CCRCC

Explore this scatter interactively →