Hexose catabolic process

Across TCGA cell cohorts, RNA activity of the Hexose catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKM, ENO1, and TP53, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKM grouped by Hexose catabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PKM →	-0.360	-0.967	<.001	<.001	3	10
BREAST	ENO1 →	-0.256	-1.129	<.001	<.001	3	7
SKIN	TP53 →	-0.828	-1.346	<.001	<.001	3	6
CNS	MLC1 →	-0.476	-1.070	.001	.003	3	6
LUNG_NSCLC_LUAD	GAPDH →	-0.510	-1.090	<.001	<.001	3	5
SOFT_TISSUE	RPL22 →	-0.369	-1.538	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKM by Hexose catabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →