N-acetylneuraminate catabolic process

Across TCGA patient cohorts, RNA activity of the N-acetylneuraminate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRAF3IP3, FMNL1_S1031, and TNFAIP8L2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylneuraminate catabolic process activity versus TRAF3IP3 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRAF3IP3 →	+0.657	+0.055	<.001	.004	3	7
LSCC	FMNL1_S1031 →	+0.615	+0.060	<.001	<.001	3	7
GBM	TNFAIP8L2 →	+0.425	+0.052	.005	<.001	3	7
LSCC	APBB1IP →	+0.423	+0.072	<.001	<.001	3	7
UCEC	RENBP →	+0.678	+0.091	<.001	.002	1	8
GBM	DAB2 →	+0.559	+0.046	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019262 vs TRAF3IP3 — GBM

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