N-acetylneuraminate catabolic process

Across TCGA patient cohorts, RNA activity of the N-acetylneuraminate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPING1, CD33, and LY86, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylneuraminate catabolic process activity versus SERPING1 in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPING1 →	+1.186	+0.128	.001	.009	3	6
GBM	CD33 →	+0.518	+0.082	<.001	<.001	3	6
UCEC	LY86 →	+0.777	+0.170	<.001	.001	3	6
GBM	PLCB2 →	+1.119	+0.114	<.001	<.001	3	6
LSCC	TMEM52B →	+0.633	+0.101	.005	<.001	3	6
BRCA	MS4A14 →	+1.082	+0.129	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019262 vs SERPING1 — OV

Explore this scatter interactively →