N-acetylneuraminate catabolic process

Across TCGA cell cohorts, RNA activity of the N-acetylneuraminate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAGK, GNPDA1, and PGLS, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylneuraminate catabolic process activity versus NAGK in BONE (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NAGK →	+2.071	+1.071	<.001	.001	3	11
LARGE_INTESTINE	GNPDA1 →	+1.322	+0.734	<.001	.003	3	11
BREAST	PGLS →	+1.207	+1.048	.001	<.001	3	6
BONE	COPE →	+0.608	+1.135	.002	.002	3	6
BONE	CAP1 →	+1.105	+0.986	<.001	.008	3	6
BONE	SEC31A →	+0.665	+0.995	.004	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019262 vs NAGK — BONE

Explore this scatter interactively →