Citrulline biosynthetic process

Across TCGA patient cohorts, RNA activity of the Citrulline biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAD, DLG5, and SLX4, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrulline biosynthetic process activity versus CAD in CHOL (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	CAD →	+0.939	+0.132	.008	.001	2	31
UCS	DLG5 →	+1.633	+0.087	<.001	<.001	3	28
SCLC	SLX4 →	+1.179	+0.255	<.001	<.001	3	28
UVM	ATAD2B →	+0.739	+0.082	<.001	<.001	2	29
CHOL	GON4L →	+0.900	+0.115	.002	<.001	1	29
SCLC	DNMT3A →	+2.183	+0.285	<.001	<.001	2	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019240 vs CAD — CHOL

Explore this scatter interactively →