Citrulline biosynthetic process

Across TCGA patient cohorts, RNA activity of the Citrulline biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2_S20, UTP4, and XPO1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrulline biosynthetic process activity versus RRM2_S20 in BRCA (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RRM2_S20 →	+0.932	+0.074	.001	<.001	3	8
UCEC	UTP4 →	+0.405	+0.096	<.001	<.001	3	8
LSCC	XPO1 →	+0.304	+0.069	<.001	<.001	3	8
BRCA	UTP15 →	+0.374	+0.081	<.001	<.001	3	8
LSCC	WDR75 →	+0.352	+0.097	<.001	<.001	3	8
LSCC	BRIX1 →	+0.378	+0.081	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019240 vs RRM2_S20 — BRCA

Explore this scatter interactively →