Citrulline biosynthetic process

Across TCGA patient cohorts, RNA activity of the Citrulline biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGCR8, PLEKHA7, and LDB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrulline biosynthetic process activity versus DGCR8 in BRCA (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DGCR8 →	-0.388	-0.162	<.001	<.001	3	5
BRCA	PLEKHA7 →	-0.430	-0.126	<.001	<.001	3	5
LUAD	LDB3 →	-0.215	-0.110	.003	.004	3	5
LUAD	CBLB →	-0.370	-0.137	.002	.008	3	4
BRCA	VIPR1 →	-0.690	-0.112	.006	.001	3	4
UCEC	NCOA3 →	-0.276	-0.211	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019240 vs DGCR8 — BRCA

Explore this scatter interactively →