Citrulline biosynthetic process

Across TCGA cell cohorts, RNA activity of the Citrulline biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPR3, KIF1A, and NPTXR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPR3 grouped by Citrulline biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NPR3 →	-0.310	-0.228	.004	.001	3	4
STOMACH	KIF1A →	-2.781	-0.233	.003	.004	3	4
STOMACH	NPTXR →	-2.562	-0.325	<.001	<.001	3	4
CNS	TMEM151A →	-0.265	-0.363	.007	.005	2	4
STOMACH	SV2A →	-2.363	-0.205	.002	.002	2	4
BLOOD_Myeloma	TM4SF19 →	+0.197	+0.216	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPR3 by Citrulline biosynthetic process activity — STOMACH

Explore this box plot interactively →