Citrulline biosynthetic process

Across TCGA cell cohorts, RNA activity of the Citrulline biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3C, SRPX2, and SKP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrulline biosynthetic process activity versus POLR3C in SKIN (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	POLR3C →	+0.660	+0.277	<.001	.001	3	4
BONE	SRPX2 →	-3.041	-0.258	<.001	.002	3	4
BONE	SKP2 →	+1.564	+0.254	.009	.002	3	4
BONE	TMEM161A →	+1.210	+0.282	<.001	<.001	3	4
BONE	SNRPA →	+0.427	+0.282	.005	.004	3	4
LUNG_NSCLC_LUSC	DDAH1 →	+2.030	+0.407	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019240 vs POLR3C — SKIN

Explore this scatter interactively →