Citrulline biosynthetic process

Across TCGA cell cohorts, RNA activity of the Citrulline biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAD, CPS1, and CTPS1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrulline biosynthetic process activity versus CAD in PANCREAS (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CAD →	+2.260	+0.400	<.001	.002	3	15
STOMACH	CPS1 →	+3.186	+0.558	<.001	<.001	3	13
PANCREAS	CTPS1 →	+2.120	+0.307	.001	<.001	3	11
PANCREAS	USP14 →	+2.281	+0.437	<.001	<.001	3	10
PANCREAS	TCP1 →	+2.201	+0.470	<.001	<.001	3	10
PANCREAS	CCT6B →	+2.228	+0.398	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019240 vs CAD — PANCREAS

Explore this scatter interactively →