Sensory perception of pain

Across TCGA patient cohorts, RNA activity of the Sensory perception of pain pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRMT61A, TYMP, and AHCY, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of pain activity versus TRMT61A in PDAC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TRMT61A →	-0.363	-0.027	<.001	<.001	3	5
GBM	TYMP →	+0.500	+0.031	.001	.004	3	5
LSCC	AHCY →	-0.381	-0.031	<.001	.003	3	5
PDAC	TLE3_S203 →	-0.388	-0.024	.002	.008	3	5
PDAC	RBM14_T206 →	-0.564	-0.024	<.001	<.001	3	5
OV	TAP1 →	+0.448	+0.030	.007	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019233 vs TRMT61A — PDAC

Explore this scatter interactively →