Sensory perception of pain

Across TCGA cell cohorts, RNA activity of the Sensory perception of pain pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD3, TMEM169, and H4C2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFSD3 grouped by Sensory perception of pain-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MFSD3 →	-0.877	-0.796	<.001	.001	3	5
KIDNEY	TMEM169 →	-1.208	-1.087	.002	.005	3	4
BLOOD_Myeloma	H4C2 →	+0.618	+1.195	.008	<.001	2	5
LUNG_SCLC	STARD8 →	-1.155	-1.079	.001	<.001	3	4
LUNG_NSCLC_LUSC	IL13RA1 →	-1.088	-1.265	.001	<.001	3	4
SOFT_TISSUE	CARHSP1 →	+1.267	+0.923	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFSD3 by Sensory perception of pain activity — OESOPHAGUS

Explore this box plot interactively →