Sensory perception of pain

Across TCGA cell cohorts, RNA activity of the Sensory perception of pain pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA8H, TNS4, and NUCB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of pain activity versus GOLGA8H in LUNG_SCLC (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GOLGA8H →	-0.994	-1.329	.001	<.001	3	4
URINARY_TRACT	TNS4 →	+5.888	+1.609	<.001	.005	3	4
SOFT_TISSUE	NUCB1 →	-0.581	-1.507	<.001	.001	3	4
KIDNEY	OSTC →	-0.681	-1.737	.006	<.001	3	4
URINARY_TRACT	ITGA2 →	+2.711	+1.100	<.001	.004	3	4
URINARY_TRACT	KCNK6 →	+2.080	+1.576	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019233 vs GOLGA8H — LUNG_SCLC

Explore this scatter interactively →