Proprioception

pathway activity — cross-omics
GO:0019230Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Proprioception pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCD5, CEBPB, and NAMPT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECSCD5 →+0.818+0.128.001.00236
OVCEBPB →-0.392-0.053.008.00935
CCRCCNAMPT →-0.552-0.057<.001<.00135
LSCCENOPH1 →+0.156+0.056.008.00335
PDACCCNE1_S103 →-1.022-0.075<.001<.00134
UCECCDR2L →-0.568-0.113.002.00434
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration