Proprioception

pathway activity — cross-omics
GO:0019230Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Proprioception pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D13, GPR107, and DSN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCTBC1D13 →-0.385-0.650<.001.00234
PDACGPR107 →-0.254-0.696.002.00334
LSCCDSN1 →-0.421-0.709.002.00334
LSCCGAREM2 →-0.675-0.533<.001.00234
LSCCC6orf132 →-0.875-0.883<.001<.00134
LSCCLSM2 →-0.510-0.727<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration