Neuronal action potential

Across TCGA patient cohorts, RNA activity of the Neuronal action potential pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SP100_S362, CAMSAP3, and TBC1D2B_S155, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal action potential activity versus SP100_S362 in HNSC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SP100_S362 →	-0.484	-0.037	<.001	.003	3	6
LSCC	CAMSAP3 →	+0.390	+0.035	<.001	<.001	3	6
OV	TBC1D2B_S155 →	-0.581	-0.031	<.001	<.001	3	6
LSCC	ZAP70 →	-0.590	-0.043	<.001	.002	3	6
COAD	EHD2_S438 →	-0.279	-0.028	.001	.001	3	6
COAD	RASA3 →	-0.335	-0.046	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019228 vs SP100_S362 — HNSC

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