Neuronal action potential

Across TCGA patient cohorts, RNA activity of the Neuronal action potential pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, ADHFE1, and IKBIP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal action potential activity versus ANK3 in GBM (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANK3 →	+1.294	+0.651	<.001	<.001	3	8
OV	ADHFE1 →	+0.514	+0.613	<.001	<.001	3	6
GBM	IKBIP →	-0.433	-0.533	<.001	<.001	3	6
GBM	EMP3 →	-0.732	-0.587	.001	<.001	2	6
CCRCC	ADH6 →	+0.714	+0.640	<.001	<.001	3	5
OV	NAPEPLD →	+0.557	+0.524	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019228 vs ANK3 — GBM

Explore this scatter interactively →