Neuronal action potential

Across TCGA cell cohorts, RNA activity of the Neuronal action potential pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTKN, SLC38A10, and ZNF791, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RTKN grouped by Neuronal action potential-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RTKN →	-1.225	-0.593	<.001	.008	3	3
LUNG_NSCLC_LUAD	SLC38A10 →	-0.622	-0.604	.005	.009	3	3
LARGE_INTESTINE	ZNF791 →	-0.818	-0.919	<.001	.005	3	3
LARGE_INTESTINE	SRSF5 →	-0.437	-0.822	.005	.004	3	3
LARGE_INTESTINE	UVSSA →	-0.920	-1.222	<.001	<.001	3	3
SOFT_TISSUE	MTLN →	+1.247	+0.777	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RTKN by Neuronal action potential activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →