Neuronal action potential

Across TCGA cell cohorts, RNA activity of the Neuronal action potential pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAAF5, CRK, and ZCCHC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAAF5 grouped by Neuronal action potential-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DNAAF5 →	+0.193	+0.093	.002	.008	3	5
LIVER	CRK →	-0.285	-0.260	.001	.002	3	5
CNS	ZCCHC3 →	-0.271	-0.134	.007	.006	3	5
UPPER_AERODIGESTIVE_TRACT	CAMLG →	+0.221	+0.204	.002	.003	3	5
LUNG_SCLC	ITGAV →	-0.780	-0.168	.001	<.001	3	5
LUNG_NSCLC_LUSC	CD300A →	+0.208	+0.116	.003	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAAF5 by Neuronal action potential activity — LUNG_SCLC

Explore this box plot interactively →