Neuronal action potential

Across TCGA cell cohorts, RNA activity of the Neuronal action potential pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH14, PLXNA2, and APOO, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal action potential activity versus MYH14 in URINARY_TRACT (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MYH14 →	+4.387	+1.762	<.001	<.001	3	6
LUNG_SCLC	PLXNA2 →	+1.598	+0.830	.003	.002	3	5
UPPER_AERODIGESTIVE_TRACT	APOO →	-1.072	-1.872	.006	<.001	3	5
OESOPHAGUS	NOSTRIN →	+1.182	+0.890	.006	.006	2	5
LUNG_SCLC	RNF141 →	+0.661	+1.040	.003	.001	3	4
LUNG_SCLC	RPL26 →	-0.799	-0.950	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019228 vs MYH14 — URINARY_TRACT

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