Transmission of nerve impulse

Across TCGA patient cohorts, RNA activity of the Transmission of nerve impulse pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AVPI1, RRAS, and DEFB131B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transmission of nerve impulse activity versus AVPI1 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AVPI1 →	+0.613	+1.051	.001	.003	3	4
LUAD	RRAS →	+0.384	+0.265	.002	.006	3	4
LSCC	DEFB131B →	-0.627	-0.601	.004	.004	3	4
HNSC	TUBA4A →	+1.145	+0.208	.006	.008	3	4
HNSC	ITGA3 →	+1.312	+0.256	<.001	<.001	3	4
HNSC	JADE1 →	-0.460	-0.189	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019226 vs AVPI1 — GBM

Explore this scatter interactively →