Transmission of nerve impulse

Across TCGA patient cohorts, RNA activity of the Transmission of nerve impulse pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLEC, PLEC_S569, and PLEC_S720, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transmission of nerve impulse activity versus PLEC in HNSC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLEC →	+0.503	+0.299	<.001	<.001	3	7
BRCA	PLEC_S569 →	+0.604	+0.572	<.001	.001	1	7
BRCA	PLEC_S720 →	+0.604	+0.572	<.001	.001	1	7
HNSC	PLEC_T3634 →	+0.799	+0.348	<.001	<.001	3	5
HNSC	PLEC_T3785 →	+0.799	+0.348	<.001	<.001	3	5
HNSC	EHMT1_S435 →	-0.541	-0.298	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019226 vs PLEC — HNSC

Explore this scatter interactively →