Transmission of nerve impulse

Across TCGA cell cohorts, RNA activity of the Transmission of nerve impulse pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRT1, ZBTB5, and AZIN1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transmission of nerve impulse activity versus SIRT1 in KIDNEY (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SIRT1 →	-0.563	-0.498	.002	<.001	3	3
BONE	ZBTB5 →	-1.006	-0.294	.001	.008	3	3
LUNG_SCLC	AZIN1 →	+0.664	+0.468	<.001	.001	3	3
LARGE_INTESTINE	OVOL2 →	+1.360	+0.215	.008	.002	3	3
LARGE_INTESTINE	ZFP37 →	-0.865	-0.228	.003	.002	3	3
LARGE_INTESTINE	ZNF697 →	-1.090	-0.291	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019226 vs SIRT1 — KIDNEY

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