Nonribosomal peptide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nonribosomal peptide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASNS, USP24, and MYLK_S1209, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nonribosomal peptide biosynthetic process activity versus ASNS in HNSC (Pearson r = 0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ASNS →	+0.426	+0.045	<.001	.006	3	4
HNSC	USP24 →	-0.200	-0.064	.001	.006	3	4
HNSC	MYLK_S1209 →	+0.834	+0.055	.001	.007	3	4
OV	PHGDH →	+0.630	+0.030	.002	.008	3	4
GBM	DR1 →	-0.326	-0.054	<.001	<.001	3	4
LSCC	MAP2_T1628 →	+1.558	+0.069	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019184 vs ASNS — HNSC

Explore this scatter interactively →