Nonribosomal peptide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nonribosomal peptide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNGR1, FBXO27, and JAKMIP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nonribosomal peptide biosynthetic process activity versus SYNGR1 in GBM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYNGR1 →	+0.984	+0.332	<.001	<.001	3	4
LSCC	FBXO27 →	+0.809	+0.106	<.001	.006	3	4
LSCC	JAKMIP3 →	+1.083	+0.200	<.001	<.001	3	4
HNSC	SLC7A11-AS1 →	+0.971	+0.109	<.001	.001	3	4
LSCC	ADD2 →	+1.147	+0.154	.001	<.001	3	4
GBM	CLYBL →	+0.390	+0.235	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019184 vs SYNGR1 — GBM

Explore this scatter interactively →