Nonribosomal peptide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nonribosomal peptide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2Q2, RAB18, and KHK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE2Q2 grouped by Nonribosomal peptide biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	UBE2Q2 →	-0.656	-1.209	<.001	.003	3	4
URINARY_TRACT	RAB18 →	-0.703	-1.817	.004	<.001	3	4
BLOOD_Myeloma	KHK →	+1.115	+1.405	<.001	<.001	3	4
LARGE_INTESTINE	TMEM234 →	-0.640	-0.917	.001	.004	3	4
OVARY	C6orf62 →	-0.554	-1.036	.001	.006	3	4
BLOOD_Myeloma	CMPK1 →	-1.174	-1.784	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE2Q2 by Nonribosomal peptide biosynthetic process activity — LIVER

Explore this box plot interactively →