Nonribosomal peptide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nonribosomal peptide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF546, ACBD5, and ANAPC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nonribosomal peptide biosynthetic process activity versus ZNF546 in BLOOD_Leukemia (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF546 →	+0.516	+0.238	.001	.003	3	6
BLOOD_Leukemia	ACBD5 →	+0.914	+0.296	.001	<.001	3	5
URINARY_TRACT	ANAPC1 →	+0.667	+1.796	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	GSTM4 →	+2.097	+1.500	<.001	.002	3	5
OVARY	RSAD1 →	+0.852	+1.351	.004	.001	3	5
LUNG_SCLC	ESD →	+0.726	+0.243	.009	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019184 vs ZNF546 — BLOOD_Leukemia

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