Reproductive behavior

Across TCGA patient cohorts, RNA activity of the Reproductive behavior pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDCA8_S219, NCAPG, and SRRM2_S1444, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reproductive behavior activity versus CDCA8_S219 in BRCA (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA8_S219 →	-0.730	-0.030	.001	<.001	3	5
UCEC	NCAPG →	-0.525	-0.047	<.001	.004	3	5
BRCA	SRRM2_S1444 →	-0.595	-0.028	.001	.002	3	4
GBM	SUPT6H →	-0.204	-0.057	.009	.001	3	4
UCEC	ALDH9A1 →	+0.385	+0.050	<.001	.001	3	4
CCRCC	PURB →	+0.176	+0.039	.005	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019098 vs CDCA8_S219 — BRCA

Explore this scatter interactively →