Reproductive behavior

Across TCGA patient cohorts, RNA activity of the Reproductive behavior pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf162, CD163, and IFITM3P2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reproductive behavior activity versus C1orf162 in PDAC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	C1orf162 →	-0.369	-0.102	.001	.008	3	3
PDAC	CD163 →	-0.398	-0.183	.004	.004	3	3
HNSC	IFITM3P2 →	+0.772	+0.130	<.001	.001	3	3
PDAC	WDR62 →	-0.505	-0.274	<.001	.006	3	3
BRCA	CLEC10A →	+0.920	+0.161	.005	.002	3	3
GBM	CYP2U1 →	+0.459	+0.256	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019098 vs C1orf162 — PDAC

Explore this scatter interactively →