Reproductive behavior

Across TCGA cell cohorts, RNA activity of the Reproductive behavior pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF1, CUZD1, and EIF2B5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAPGEF1 grouped by Reproductive behavior-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RAPGEF1 →	-0.967	-0.684	<.001	.003	3	4
SOFT_TISSUE	CUZD1 →	+0.764	+1.296	.004	.002	3	3
LUNG_NSCLC_LUSC	EIF2B5 →	+0.886	+1.127	.002	.001	2	4
CNS	SURF4 →	-0.586	-1.065	<.001	<.001	2	4
CNS	F2RL1 →	-3.034	-1.117	<.001	.001	3	3
LUNG_NSCLC_LUSC	ELFN2 →	-2.024	-1.336	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAPGEF1 by Reproductive behavior activity — OESOPHAGUS

Explore this box plot interactively →