Reproductive behavior

Across TCGA cell cohorts, RNA activity of the Reproductive behavior pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC102B, ITGA3, and SH3BGRL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reproductive behavior activity versus CCDC102B in KIDNEY (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CCDC102B →	+1.492	+1.403	.005	.009	3	4
LARGE_INTESTINE	ITGA3 →	+1.326	+0.976	.006	.004	3	4
OVARY	SH3BGRL →	+1.137	+1.011	.003	.008	2	5
SOFT_TISSUE	WDCP →	-0.642	-1.115	.003	.004	2	4
OESOPHAGUS	NGRN →	-0.741	-0.676	.005	.009	3	3
LIVER	BBS5 →	+2.210	+1.641	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019098 vs CCDC102B — KIDNEY

Explore this scatter interactively →