Viral transcription

Across TCGA cell cohorts, RNA activity of the Viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDRT4, AVPI1, and THAP6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDRT4 grouped by Viral transcription-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CDRT4 →	+1.094	+0.251	<.001	.004	3	4
PANCREAS	AVPI1 →	-0.985	-0.188	.008	.004	3	4
LUNG_SCLC	THAP6 →	+0.783	+0.349	.003	.001	3	3
LUNG_SCLC	MAGEA6 →	+4.434	+0.337	.002	.001	3	3
SOFT_TISSUE	SOD2 →	+1.272	+0.294	.005	.007	3	3
SOFT_TISSUE	ALAS1 →	+0.642	+0.217	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDRT4 by Viral transcription activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →