Viral transcription

Across TCGA cell cohorts, RNA activity of the Viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNT2, AP1G1, and KIAA0895L, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral transcription activity versus CCNT2 in LUNG_NSCLC_LUSC (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCNT2 →	+1.112	+0.159	.001	<.001	3	18
STOMACH	AP1G1 →	+0.991	+0.141	.002	<.001	3	18
BONE	KIAA0895L →	+1.621	+0.147	<.001	<.001	3	18
BONE	MON1B →	+1.202	+0.130	<.001	<.001	3	18
BREAST	TAF1C →	+1.119	+0.127	<.001	<.001	3	18
BREAST	TMEM170A →	+0.869	+0.098	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019083 vs CCNT2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →