Viral protein processing

Across TCGA patient cohorts, RNA activity of the Viral protein processing pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVL, ACAP1_T739, and NFATC2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral protein processing activity versus EVL in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EVL →	+0.514	+0.033	<.001	.001	3	8
LSCC	ACAP1_T739 →	+0.620	+0.041	<.001	<.001	3	8
GBM	NFATC2 →	+0.323	+0.047	<.001	<.001	3	7
LSCC	ARHGAP15_S64 →	+0.687	+0.047	<.001	<.001	3	7
CCRCC	DOCK10 →	+0.332	+0.037	<.001	.002	3	7
GBM	AIF1 →	+0.686	+0.054	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019082 vs EVL — BRCA

Explore this scatter interactively →