Viral protein processing

Across TCGA cell cohorts, RNA activity of the Viral protein processing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCEAL3, ZNF599, and SAP30L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCEAL3 grouped by Viral protein processing-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TCEAL3 →	-1.456	-0.938	<.001	.008	3	5
LIVER	ZNF599 →	-1.193	-1.737	.001	.005	3	4
LIVER	SAP30L →	-1.112	-2.135	<.001	<.001	2	5
KIDNEY	SERPINB6 →	-0.615	-1.204	<.001	.002	3	4
CNS	RIMS1 →	-0.791	-0.742	<.001	.002	3	3
LIVER	TRIM37 →	-1.018	-1.529	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCEAL3 by Viral protein processing activity — LUNG_SCLC

Explore this box plot interactively →