Viral protein processing

Across TCGA cell cohorts, RNA activity of the Viral protein processing pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPNE7, G6PD, and SPRYD7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral protein processing activity versus CPNE7 in OVARY (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CPNE7 →	-3.086	-0.240	<.001	.003	3	5
LUNG_NSCLC_LUSC	G6PD →	-2.938	-0.284	.004	.001	3	5
BREAST	SPRYD7 →	-0.564	-0.148	.008	.004	3	5
OVARY	PSMB5 →	-0.605	-0.181	<.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	GSR →	-1.301	-0.179	<.001	.003	3	4
OVARY	IMP4 →	-0.811	-0.215	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019082 vs CPNE7 — OVARY

Explore this scatter interactively →