Viral translation

Across TCGA patient cohorts, RNA activity of the Viral translation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATRX, TMOD2, and PPP1R12B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral translation activity versus ATRX in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ATRX →	+0.258	+0.083	<.001	.007	3	5
LSCC	TMOD2 →	+0.295	+0.038	<.001	<.001	3	5
BRCA	PPP1R12B →	+0.307	+0.026	.002	<.001	3	5
COAD	PTDSS1_S442 →	-0.790	-0.034	<.001	<.001	2	6
HNSC	RAB3D →	-0.524	-0.109	<.001	<.001	3	5
OV	MX2 →	+0.653	+0.048	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019081 vs ATRX — HNSC

Explore this scatter interactively →