Viral translation

Across TCGA patient cohorts, RNA activity of the Viral translation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN5, MANBA, and H3-3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral translation activity versus TSPAN5 in LSCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TSPAN5 →	-0.518	-0.099	.001	.006	3	4
UCEC	MANBA →	-0.331	-0.104	.006	.002	3	3
UCEC	H3-3B →	-0.443	-0.123	.004	<.001	3	3
OV	BBC3 →	-0.776	-0.208	<.001	<.001	3	3
OV	DDB2 →	-0.598	-0.200	.002	<.001	3	3
OV	C19orf48 →	-0.677	-0.219	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019081 vs TSPAN5 — LSCC

Explore this scatter interactively →