Viral translation

Across TCGA cell cohorts, RNA activity of the Viral translation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOLC1, NUDC, and KHSRP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral translation activity versus NOLC1 in PANCREAS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NOLC1 →	+1.100	+0.535	.003	<.001	3	7
PANCREAS	NUDC →	+0.877	+0.488	.001	.002	3	7
PANCREAS	KHSRP →	+1.087	+0.634	.001	.001	3	6
LUNG_SCLC	CDT1 →	+0.383	+0.220	.005	.002	3	6
PANCREAS	LSM12 →	+1.011	+0.600	<.001	<.001	3	6
PANCREAS	CCT4 →	+0.826	+0.562	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019081 vs NOLC1 — PANCREAS

Explore this scatter interactively →