Viral gene expression

Across TCGA patient cohorts, RNA activity of the Viral gene expression pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D2B, LCP1, and GRAP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral gene expression activity versus TBC1D2B in GBM (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TBC1D2B →	+0.278	+0.032	<.001	<.001	3	7
GBM	LCP1 →	+0.836	+0.046	<.001	<.001	3	7
BRCA	GRAP2 →	+0.337	+0.027	.001	<.001	3	7
HNSC	PLAC9 →	+0.897	+0.055	<.001	.007	3	7
GBM	IL16 →	+0.687	+0.053	<.001	<.001	3	7
GBM	SEPTIN1 →	+1.150	+0.053	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019080 vs TBC1D2B — GBM

Explore this scatter interactively →