Viral gene expression

Across TCGA cell cohorts, RNA activity of the Viral gene expression pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDH2, THOP1, and EIF4H, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral gene expression activity versus MDH2 in SKIN (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MDH2 →	+1.003	+0.334	.007	.001	2	7
PANCREAS	THOP1 →	+1.094	+0.353	.002	.001	3	6
LIVER	EIF4H →	+0.491	+0.335	.006	.006	3	6
LARGE_INTESTINE	CRLF3 →	+0.745	+0.264	<.001	<.001	3	6
STOMACH	CDT1 →	+1.441	+0.401	.004	<.001	2	6
STOMACH	PA2G4 →	+1.027	+0.341	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019080 vs MDH2 — SKIN

Explore this scatter interactively →