Viral genome replication

Across TCGA patient cohorts, RNA activity of the Viral genome replication pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CMPK2, MX2, and STAT2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral genome replication activity versus CMPK2 in BRCA (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CMPK2 →	+0.643	+0.043	<.001	<.001	3	10
GBM	MX2 →	+1.040	+0.068	<.001	<.001	3	10
GBM	STAT2 →	+0.578	+0.053	<.001	<.001	3	9
COAD	XAF1 →	+0.977	+0.034	<.001	<.001	3	9
UCEC	IFIT3 →	+1.032	+0.075	<.001	<.001	3	9
GBM	IRF9 →	+0.400	+0.041	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019079 vs CMPK2 — BRCA

Explore this scatter interactively →