Viral genome replication

Across TCGA patient cohorts, RNA activity of the Viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRM2, RPL5P32, and RPL34P1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral genome replication activity versus RRM2 in BRCA (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RRM2 →	+1.257	+0.297	.001	<.001	3	2
BRCA	RPL5P32 →	-0.245	-0.281	.006	.007	3	2
BRCA	RPL34P1 →	-0.390	-0.304	.001	.006	3	2
OV	CCL17 →	-0.938	-0.185	.002	<.001	3	2
OV	GMNN →	+1.052	+0.169	.002	.008	3	2
OV	RNF149 →	-0.499	-0.202	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019079 vs RRM2 — BRCA

Explore this scatter interactively →