Viral release from host cell

Across TCGA patient cohorts, RNA activity of the Viral release from host cell pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPB41L1_S784, MAP1B, and NIPBL_S2672, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral release from host cell activity versus EPB41L1_S784 in HNSC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EPB41L1_S784 →	+0.888	+0.057	<.001	.002	3	5
BRCA	MAP1B →	+0.504	+0.023	<.001	<.001	3	5
COAD	NIPBL_S2672 →	-0.703	-0.035	<.001	<.001	3	5
LUAD	SRP68 →	-0.169	-0.037	<.001	.001	3	5
UCEC	ATXN1L_S62 →	+1.394	+0.054	<.001	.009	3	5
PDAC	RPS2 →	-0.242	-0.041	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019076 vs EPB41L1_S784 — HNSC

Explore this scatter interactively →