Viral release from host cell

Across TCGA cell cohorts, RNA activity of the Viral release from host cell pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP3A5, TATDN1, and COPRS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP3A5 grouped by Viral release from host cell-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CYP3A5 →	+1.843	+0.221	<.001	<.001	3	4
BLOOD_Leukemia	TATDN1 →	+0.860	+0.174	<.001	<.001	3	4
BLOOD_Leukemia	COPRS →	-1.117	-0.261	<.001	<.001	3	4
BLOOD_Leukemia	CSKMT →	-0.844	-0.189	.001	<.001	3	4
LUNG_SCLC	RPUSD3 →	-0.805	-0.178	<.001	.001	3	4
KIDNEY	AGO2 →	+0.855	+0.251	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP3A5 by Viral release from host cell activity — LARGE_INTESTINE

Explore this box plot interactively →